Publications

Ekas et al., 2006 

Amoyel M, Simons BD, Bach EA. 2014. Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo. The EMBO Journal doi:10.15252/embj.201387500. PubMed (Featured In: The EMBO Journal PubMed)

Amoyel M, Anderson AM, Bach EA. 2014. JAK/STAT pathway dysregulation in tumors: a Drosophila perspective. Seminars in Cell & Developmental Biology 28, 96-103. PubMed

Amoyel M & Bach EA. 2014. Cell competition: how to eliminate your neighbours. Development 141, 988-1000. PubMed

Court H, Amoyel M, Hackman M, Lee KE, Xu R, Miller G, Bar-Sagi D, Bach EA, Bergö MO, Philips MR. 2013. Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. The Journal of Clinical Investigation 123, 4681-94. PubMed

Zoranovic T, Grmai L, Bach EA. 2013. Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway. JAK-STAT 2, e25408. PubMed

Ayala-Camargo A, Anderson AM, Amoyel M, Rodrigues AB, Flaherty MS, Bach EA. 2013. JAK/STAT signaling is required for hinge growth and patterning in the Drosophila wing disc. Developmental Biology 382, 413-26. PubMed

Amoyel M, Sanny J, Burel M, Bach EA. 2013. Hedgehog is required for CySC self-renewal but does not contribute to the GSC niche in the Drosophila testis. Development 140, 56-65. PubMed

Rodrigues AB, Zoranovic T, Ayala-Camargo A, Grewal S, Reyes-Robles T, Krasny M, Wu DC, Johnston LA, Bach EA. 2012. Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis. Development 139, 4051-61. PubMed (Featured In: Development Link)

Amoyel M & Bach EA. 2012. Functions of Drosophila JAK/STAT pathway: lessons from stem cells. JAK-STAT 1, 176-83. PubMed

Yin CH, Bach EA, Baeg GH. 2011. Development of a high-throughput cell-based reporter assay for screening of JAK3 inhibitors. Journal of Biomolecular Screening 16, 443-9. PubMed

Kim BH, Kim M, Yin CH, Jee JG, Sandoval C, Lee H, Bach EA, Hahm DH, Baeg GH. 2011. Inhibition of JAK3 alleviates inflammation in monoarthritic rats. British Journal of Pharmacology 164, 106-18. PubMed

Sung PJ#, Rodrigues AB#, Kleinberger A, Quatela S, Bach EA*, Philips MR*. 2010. Cytosolic Ras supports eye development in Drosophila. Molecular and Cellular Biology 30, 5649-57. (# co-first authors; * co-corresponding authors). PubMed

Ekas LA, Cardozo TJ, Flaherty MS, McMillan E, Gonsalves F, Bach EA. 2010. Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila. Developmental Biology 344, 621-36. PubMed

Flaherty MS, Salis P, Evans CJ, Ekas LA, Marouf A, Zavadil J, Banerjee U, Bach EA. 2010. chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. Developmental Cell 18, 556-68. PubMed

Kim BH, Jee JG, Yin CH, Sandoval C, Jayabose S, Kitamura D, Bach EA, Baeg GH. 2010. NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3. Molecular Cancer 9, 36. PubMed

Kim K, Oh SR, Yin CH, Lee S, Kim EA, Kim MS, Sandoval C, Jayabose S, Bach EA, Lee HK, Baeg GH. 2010. MS-1020, a novel small molecule, selectively inhibits JAK3/STAT signaling. British Journal of Haematology 148, 132-43. PubMed

Flaherty MS, Zavadil J, Ekas LA, Bach EA. 2009. Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of Notch signaling by the JAK/STAT pathway. Developmental Dynamics 238, 2235-53. PubMed

Kim BH, Yin CH, Guo Q, Bach EA, Lee H, Sandoval C, Jayabose S, Ulaczyk-Lesanko A, Hall DG, Baeg GH. 2008. A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signalling in human cancer cells. Molecular Cancer Therapeutics 7, 2672-80. PubMed

Ayala-Camargo A, Ekas LA, Flaherty MS, Baeg GH, Bach EA. 2007. The JAK/STAT pathway regulates proximo-distal patterning in Drosophila. Developmental Dynamics 236, 2721-30. PubMed

Bach EA, Ekas LA, Ayala-Camargo A, Flaherty MS, Lee H, Perrimon N, Baeg GH. 2007. GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Gene Expression Patterns 7, 323-31. PubMed

Tolwinski NS. 2007. New advances in signaling and pattern formation. Fly 1, 116-7. PubMed

Ekas LA, Baeg GH, Flaherty MS, Ayala-Camargo A, Bach EA. 2006. JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila. Development 133, 4721-9. PubMed (Featured In: Development Link; Fly PubMed)

Arbouzova NI, Bach EA, Zeidler MP. 2006. Ken & Barbie selectively regulates the expression of a subset of JAK/STAT pathway target genes. Current Biology 16, 80-8. PubMed

Read RD, Bach EA, Cagan RL. 2004. The Drosophila ortholog of C-terminal Src kinase negatively regulates tissue growth and cell proliferation through inhibition of Src, JNK and STAT pathways. Molecular and Cellular Biology 24, 6676-89. PubMed

Bach EA, Vincent S, Zeidler MP, Perrimon N. 2003. A sensitized genetic screen to identify novel regulators and components of the Drosophila JAK/STAT pathway. Genetics 165, 1149-66. PubMed

Bach EA & Perrimon N. 2003. Prime time for the Drosophila JAK/STAT pathway. Signal Transducers and Activators of Transcription (STATs): Activation and Biology, (Seghal PB, Levy DE, Hirano T, Eds.). Link

Ghiglione C, Bach EA, Paraiso Y, Carraway KL 3rd, Perrimon N. 2002. Mechanism of activation of the Drosophila EGF Receptor by the TGFa ligand Gurken during oogenesis. Development 129, 175-86. PubMed

Bach EA & Perrimon N. 2001. The role of the JAK-STAT pathway in hematopoiesis and immune responses in Drosophila. The JAK-STAT Pathway in Hematopoiesis and Disease, (Ward A, Ed.). Link

Zeidler MP, Bach EA, Perrimon N. 2000. The roles of the Drosophila JAK/STAT pathway. Oncogene 18, 2598-606. PubMed

Bach EA, Aguet M, Schreiber RD. 1997. The IFN-gamma receptor: a paradigm for cytokine receptor signaling. Annual Review of Immunology 15, 563-91. PubMed

Bach EA, Kaplan DH, Schreiber RD. 1997. The biochemistry, mechanism of action and biology of the interferons. Inflammation, Basic Principles and Clinical Correlates, (Gallin JI & Snyderman R, Eds.).

Bach EA & Schreiber RD. 1997. CDw119/IFN-gamma receptor workshop panel report. Leucocyte Typing VI, (Kishimoto T, Ed.).

Bach EA, Tanner JW, Marsters S, Ashkenazi A, Aguet M, Shaw AS, Schreiber RD. 1996. Ligand-induced assembly and activation of the IFN-gamma receptor in intact cells. Molecular and Cellular Biology 16, 3214-21. PubMed

Meraz MA, White JM, Sheehan KCF, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, Carver-Moore K, DuBois RN, Clark R, Aguet M, Schreiber RD. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84, 431-42. PubMed

Verbsky JW, Bach EA, Fang YF, Fang L, Randolph DA, Fields LE. 1996. Expression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cells. Journal of Biological Chemistry 271, 13976-80. PubMed

Dighe AS, Bach EA, Greenlund AC, Schreiber RD. 1996. The molecular basis of IFN gamma action. Growth Factors and Cytokines in Health and Disease Volume 2B, (LeRoith D, Ed.).

Bach EA, Szabo SJ, Dighe AS, Ashkenazi A, Aguet M, Murphy KM, Schreiber RD. 1995. Ligand induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsets. Science 270, 1215-8. PubMed

Marsters S, Pennica D, Bach E, Schreiber RD, Ashkenazi A. 1995). Interferon signals via a high-affinity multisubunit receptor complex that contains two types of polypeptide chain. Proceedings of the National Academy of Sciences of the United States of America 92, 5401-5. PubMed

Veis DJ, Sentman CL, Bach EA, Korsmeyer SJ. 1993. Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. Journal of Immunology 151, 2546-54. PubMed